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Is your lifestyle putting your liver at risk?

No one will deny that liver is a major detox factory in our body. It performs many crucial functions such as filtering our blood, detoxifying chemicals, and metabolizing drugs. What people often forget is that we’ve got only one liver to rely on.


Risk factors


The reality is that our lifestyle choices heavily influence the wellbeing of this organ. Some of the most prominent risk factors include:

  • Obesity

  • Type 2 diabetes

  • Drinking alcohol

  • Exposure to certain chemicals or toxins (including drugs and generic medicine)

On top of that, viral liver infections such as Hepatitis A, B and C may seriously threaten a person’s overall health.


As a result, liver failure may ensue and manifest itself in various diseases like cirrhosis, substance (drug/alcohol)-induced liver injury, non-alcoholic fatty liver disease, cancer, and others (1-4).


This brings up an important question: what should we do to keep our liver healthy?


Plant extracts as hepatoprotectors


Before it gets too far, it is important to remember that your health is in your own hands. Things like healthy diet, exercise and scientifically justified supplements are not overrated – they work, they save lives, they will help you too!


The amount of food supplements out there is overwhelming, and it is often hard to find the ones that work. When faced with the vast array of options, it is always a good idea to look for the natural remedies that are most researched and showed their effectiveness and safety.


When it comes to liver protection, BETULEX™ stands out as one of the most potent natural compounds as demonstrated in multiple studies.


BETULEX™ is a new breakthrough health supplement based on the birch bark extract rich in betulin.


Betulin - and its natural derivative betulinic acid – is known to have a variety of health benefits, but the strongest scientific support has been shown for (5-23):

  • fat and cholesterol reduction

  • antidiabetic

  • antimicrobial

  • liver protective effects.

If you consume alcohol regularly, take a note: studies showed that betulin extract is capable of protecting your liver cells (hepatocytes) against ethanol-induced cellular toxicity.


But even if you are not a drinker, keep in mind that a condition called non-alcohol fatty liver disease (NAFLD) may develop in people who are overweight or have diabetes, high cholesterol or high triglycerides.


If you fall into any of these categories, consider BETULEX™ as a science-backed liver protection agent which is safe and effective.


Remember that prevention is the best way to avoid these silent liver complications that may take years to develop and go unnoticed until it's too late.


References


1. Mokdad A.A., Lopez A.D., Shahraz S., Lozano R., Mokdad A.H., Stanaway J., et. al.: Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med 2014; 12: pp. 145

2. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. Jama. 2012 Feb 1;307(5):491-7.

3. Zhou B, Lu Y, Hajifathalian K, Bentham J, Di Cesare M, Danaei G, Bixby H, Cowan MJ, Ali MK, Taddei C, Lo WC. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4· 4 million participants. The Lancet. 2016 Apr 9;387(10027):1513-30.

4. Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. Journal of hepatology. 2019 Jan 1;70(1):151-71.

5. Al-Snai AE, Mousa HM, Majid WJ. Medicinal plants possessed hepatoprotective activity. IOSR Journal of Pharmacy. 2019;9(8):26-56.

6. Qadir MI, Ahmad Z. Advances in hepatoprotective medicinal plants research. ||| Bangladesh Journal of Pharmacology|||. 2017 Jul 4;12(3):229-42.

7. Ali M, Khan T, Fatima K, Ali QU, Ovais M, Khalil AT, Ullah I, Raza A, Shinwari ZK, Idrees M. Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions. Phytotherapy research. 2018 Feb;32(2):199-215.

8. Csuk R. Targeting cancer by betulin and betulinic acid. InNovel Apoptotic Regulators in Carcinogenesis 2012 (pp. 267-287). Springer, Dordrecht.

9. Adesanwo JK, Makinde OO, Obafemi CA. Phytochemical analysis and antioxidant activity of methanol extract and betulinic acid isolated from the roots of Tetracera potatoria. Journal of Pharmacy research. 2013 Sep 1;6(9):903-7.

10. Yogeeswari P, Sriram D. Betulinic acid and its derivatives: a review on their biological properties. Current medicinal chemistry. 2005 Mar 1;12(6):657-66.

11. Rzeski W, Stepulak A, Szymański M, Juszczak M, Grabarska A, Sifringer M, Kaczor J, Kandefer‐Szerszeń M. Betulin elicits anti‐cancer effects in tumour primary cultures and cell lines in vitro. Basic & clinical pharmacology & toxicology. 2009 Dec;105(6):425-32.

12. Shamsabadipour S, Ghanadian M, Saeedi H, Rahimnejad MR, Mohammadi-Kamalabadi M, Ayatollahi SM, Salimzadeh L. Triterpenes and steroids from Euphorbia denticulata Lam. with anti-Herpes symplex virus activity. Iranian journal of pharmaceutical research: IJPR. 2013;12(4):759.

13. Kim J, Lee YS, Kim CS, Kim JS. Betulinic acid has an inhibitory effect on pancreatic lipase and induces adipocyte lipolysis. Phytotherapy Research. 2012 Jul;26(7):1103-6.

14. Szuster-Ciesielska A, Kandefer-Szerszeñ M. Protective effects of betulin and betulinic acid against ethanol-induced cytotoxicity in HepG2 cells. Pharmacol Rep. 2005 Sep 1;57(5):588.

15. Wan Y, Jiang S, Lian LH, Bai T, Cui PH, Sun XT, Jin XJ, Wu YL, Nan JX. Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro. International immunopharmacology. 2013 Oct 1;17(2):184-90.

16. Wan Y, Wu YL, Lian LH, Xie WX, Li X, OuYang BQ, Bai T, Li Q, Yang N, Nan JX. The anti-fibrotic effect of betulinic acid is mediated through the inhibition of NF-κB nuclear protein translocation. Chemico-biological interactions. 2012 Feb 5;195(3):215-23.

17. Zheng ZW, Song SZ, Wu YL, Lian LH, Wan Y, Nan JX. Betulinic acid prevention of d‐galactosamine/lipopolysaccharide liver toxicity is triggered by activation of Bcl‐2 and antioxidant mechanisms. Journal of Pharmacy and Pharmacology. 2011 Apr;63(4):572-8.

18. Quan HY, Kim SJ, Jo HK, Kim GW, Chung SH. Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK–mTOR–SREBP signaling pathway. Biochemical pharmacology. 2013 May 1;85(9):1330-40.

19. Navid MH, Laszczyk-Lauer MN, Reichling J, Schnitzler P. Pentacyclic triterpenes in birch bark extract inhibit early step of herpes simplex virus type 1 replication. Phytomedicine. 2014 Sep 25;21(11):1273-80.

20. Shikov AN, Djachuk GI, Sergeev DV, Pozharitskaya ON, Esaulenko EV, Kosman VM, Makarov VG. Birch bark extract as therapy for chronic hepatitis C–a pilot study. Phytomedicine. 2011 Jul 15;18(10):807-10

21. Lin CK, Tseng CK, Chen KH, Wu SH, Liaw CC, Lee JC. Betulinic acid exerts anti‐hepatitis C virus activity via the suppression of NF‐κ B‐and MAPK‐ERK 1/2‐mediated COX‐2 expression. British journal of pharmacology. 2015 Sep;172(18):4481-92.

22. Buko V, Zavodnik I, Palecz B, Stepniak A, Kirko S, Shlyahtun A, Misiuk W, Belonovskaya E, Lukivskaya O, Naruta E, Kuzmitskaya I. Betulin/2-hydroxypropyl-β-cyclodextrin inclusion complex: Physicochemical characterization and hepatoprotective activity. Journal of Molecular Liquids. 2020 Jul 1;309:113118.


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